Melly Oitzl | Medical Pharmacology

Universiteit Leiden

Melly Oitzl, Prof. Dr.

Position:

Professor

Telephone number: +31 (0)71 527 6289
E-mail address: m.oitzl@lacdr.leidenuniv.nl
Faculty/Unit: Faculty of Science, Leiden/Amsterdam Center for Drug Research, Medical Pharmacology
Office address: Gorlaeus Laboratories
Einsteinweg 55
2333 CC Leiden
roomnumber HB-906B

2011

Strelzyk, F., Hermes, M., Naumann, E., Oitzl, M.S., Walter, C., Busch, H.P., Richter, S., Schachinger, H. , Rapid, Non-Genomic Effects of Cortisol on the Central Nervous System in Humans, Psychophysiology, vol. 48, pp. S113-S113.

Ter Horst, J.P., de Kloet, E.R., Schachinger, H., Oitzl, M.S. , Relevance of Stress and Female Sex Hormones for Emotion and Cognition, Cell Mol Neurobiol, pp. 1-11.

Daskalakis, N.P., Claessens, S.E., Laboyrie, J.J., Enthoven, L., Oitzl, M.S., Champagne, D.L., de Kloet, E.R. , The newborn rat's stress system readily habituates to repeated and prolonged maternal separation, while continuing to respond to stressors in context dependent fashion, Horm Behav, vol. 60, no. 2, pp. 165-176.

Schwabe, L., Joels, M., Roozendaal, B., Wolf, O.T., Oitzl, M.S. , Stress effects on memory: An update and integration, Neurosci Biobehav Rev.

van Tijn, P., Hobo, B., Verhage, M.C., Oitzl, M.S., van Leeuwen, F.W., Fischer, D.F. , Alzheimer-associated mutant ubiquitin impairs spatial reference memory, Physiol Behav, vol. 102, no. 2, pp. 193-200.

Schenk, G.J., Vreugdenhil, E., Hubens, C.J., Veldhuisen, B., de Kloet, E.R., Oitzl, M.S. , Hippocampal CARP over-expression solidifies consolidation of contextual fear memories, Physiol Behav, vol. 102, no. 3-4, pp. 323-331.

Claessens, S.E., Daskalakis, N.P., van der Veen, R., Oitzl, M.S., de Kloet, E.R., Champagne, D.L. , Development of individual differences in stress responsiveness: an overview of factors mediating the outcome of early life experiences, Psychopharmacology, vol. 214, no. 1, pp. 141-154.

Richter, S., Schulz, A., Zech, C.M., Oitzl, M.S., Daskalakis, N.P., Blumenthal, T.D., Schachinger, H. , Cortisol rapidly disrupts prepulse inhibition in healthy men, Psychoneuroendocrinology, vol. 36, no. 1, pp. 109-114.

Poole, D.S., Oitzl, M.S., van der Weerd, L. , MRI in animal models of psychiatric disorders, Methods Mol Biol, vol. 771, pp. 309-335.

Lass-Hennemann, J., Kuehl, L.K., Schulz, A., Oitzl, M.S., Schachinger, H. , Stress strengthens memory of first impressions of others' positive personality traits, PLoS One, vol. 6, no. 1, pp. e16389.

2010

Kuehl, L.K., Lass-Hennemann, J., Richter, S., Blumenthal, T.D., Oitzl, M.S., Schachinger, H. , Accelerated trace eyeblink conditioning after cortisol IV-infusion, Neurobiol Learn Mem, vol. 94, no. 4, pp. 547-553.

Zhou, M., Bakker, E.H., Velzing, E.H., Berger, S., Oitzl, M.S., Joels, M., Krugers, H.J. , Both mineralocorticoid and glucocorticoid receptors regulate emotional memory in mice, Neurobiol Learn Mem, vol. 94, no. 4, pp. 530-537.

van Tijn, P., Hobo, B., Verhage, M.C., Oitzl, M.S., van Leeuwen, F.W., Fischer, D.F. , Alzheimer-associated mutant ubiquitin impairs spatial reference memory, Physiol Behav, vol. 102, no. 2, pp. 193-200.

Schwabe, L., Schachinger, H., de Kloet, E.R., Oitzl, M.S. , Stress impairs spatial but not early stimulus-response learning, Behav Brain Res, vol. 213, no. 1, pp. 50-55.

Oitzl, M.S., Champagne, D.L., van der Veen, R., de Kloet, E.R. , Brain development under stress: hypotheses of glucocorticoid actions revisited, Neurosci Biobehav Rev, vol. 34, no. 6, pp. 853-866.

Schwabe, L., Schachinger, H., de Kloet, E.R., Oitzl, M.S. , Corticosteroids operate as a switch between memory systems, J Cogn Neurosci, vol. 22, no. 7, pp. 1362-1372.

Daskalakis, N.P., Fung, W.L., Schnorr, S., Meelis, W., Oitzl, M.S., de Kloet, E.R. , The three hit hypothesis of schizophrenia tested in genetically selected rats exposed to early life experience and adolescent psycho-social stressor, Int J Dev Neurosci, vol. 28, no. 8, pp. 698-698.

Schenk, G.J., Veldhuisen, B., Wedemeier, O., McGown, C.C., Schouten, T.G., Oitzl, M.S., de Kloet, E.R., Vreugdenhil, E. , Over-expression of deltaC-DCLK-short in mouse brain results in a more anxious behavioral phenotype, Physiol Behav, vol. 101, no. 4, pp. 541-548.

Enthoven, L., Schmidt, M.V., Cheung, Y.H., van der Mark, M.H., de Kloet, E.R., Oitzl, M.S. , Ontogeny of the HPA axis of the CD1 mouse following 24 h maternal deprivation at pnd 3, Int J Dev Neurosci, vol. 28, no. 2, pp. 217-224.

Strelzyk, F., Hermes, M., Naumann, E., Oitzl, M.S., Schachinger, H. , Fast, Non-Genomic Effects of Cortisol on Cerebral Blood Flow in 26 Healthy Men - a Continuous Arterial Spin Labeling (Casl) Study, Psychophysiology, vol. 47, no. Suppl. S1, pp. S48-S48.

Schwabe, L., Wolf, O.T., Oitzl, M.S. , Memory formation under stress: quantity and quality, Neurosci Biobehav Rev, vol. 34, no. 4, pp. 584-591.

Sarabdjitsingh, R.A., Spiga, F., Oitzl, M.S., Kershaw, Y., Meijer, O.C., Lightman, S.L., De Kloet, E.R. , Recovery from disrupted ultradian glucocorticoid rhythmicity reveals a dissociation between hormonal and behavioral stress responsiveness, J Neuroendocrinol, vol. 22, no. 8, pp. 862-871.

2009

Revsin, Y., Rekers, N.V., Louwe, M.C., Saravia, F.E., De Nicola, A.F., de Kloet, E.R., Oitzl, M.S. , Glucocorticoid receptor blockade normalizes hippocampal alterations and cognitive impairment in streptozotocin-induced type 1 diabetes mice, Neuropsychopharmacology, vol. 34, no. 3, pp. 747-758.

Brinks, V., Berger, S., Gass, P., de Kloet, E.R., Oitzl, M.S. , Mineralocorticoid receptors in control of emotional arousal and fear memory, Horm Behav, vol. 56, no. 2, pp. 232-238.

Brinks, V., de Kloet, E.R., Oitzl, M.S. , Corticosterone facilitates extinction of fear memory in BALB/c mice but strengthens cue related fear in C57BL/6 mice, Exp Neurol, vol. 216, no. 2, pp. 375-382.

Schwabe, L., Oitzl, M.S., Richter, S., Schachinger, H. , Modulation of spatial and stimulus-response learning strategies by exogenous cortisol in healthy young women, Psychoneuroendocrinology, vol. 34, no. 3, pp. 358-366.

Dalm, S., Schwabe, L., Schachinger, H., Oitzl, M.S. , Post-training self administration of sugar facilitates cognitive performance of male C57BL/6J mice in two spatial learning tasks, Behav Brain Res, vol. 198, no. 1, pp. 98-104.

Dalm, S., de Visser, L., Spruijt, B.M., Oitzl, M.S. , Repeated rat exposure inhibits the circadian activity patterns of C57BL/6J mice in the home cage, Behav Brain Res, vol. 196, no. 1, pp. 84-92.

2008

Dalm, S., Brinks, V., van der Mark, M.H., de Kloet, E.R., Oitzl, M.S. , Non-invasive stress-free application of glucocorticoid ligands in mice, J Neurosci Methods, vol. 170, no. 1, pp. 77-84.

de Kloet, E.R., de Jong, I.E., Oitzl, M.S. , Neuropharmacology of glucocorticoids: focus on emotion, cognition and cocaine, Eur J Pharmacol, vol. 585, no. 2-3, pp. 473-482.

Enthoven, L., de Kloet, E.R., Oitzl, M.S. , Differential development of stress system (re)activity at weaning dependent on time of disruption of maternal care, Brain Res, vol. 1217, pp. 62-69.

Revsin, Y., van Wijk, D., Saravia, F.E., Oitzl, M.S., De Nicola, A.F., de Kloet, E.R. , Adrenal hypersensitivity precedes chronic hypercorticism in streptozotocin-induced diabetes mice, Endocrinology, vol. 149, no. 7, pp. 3531-3539.

Enthoven, L., de Kloet, E.R., Oitzl, M.S. , Effects of maternal deprivation of CD1 mice on performance in the water maze and swim stress, Behav Brain Res, vol. 187, no. 1, pp. 195-199.

Enthoven, L., Oitzl, M.S., Koning, N., van der Mark, M.H., de Kloet, E.R. , Hypothalamic-pituitary-adrenal axis activity of newborn mice rapidly desensitizes to repeated maternal absence but becomes highly responsive to novelty, Endocrinology, vol. 149, no. 12, pp. 6366-6377.

De Kloet, E.R., Datson, N.A., Revsin, Y., Champagne, D.L., Oitzl, M.S. , Brain Corticosteroid Receptor Function in Response to Psychosocial Stressors, Hormones and Social Behaviour, New York;Paris;Tokyo;, Springer, pp. 131-150.

Oitzl, M.S. , Commentary: behavioral phenotype, Prog Brain Res, vol. 167, pp. 111-117.

Schwabe, L., Dalm, S., Schächinger, H., Oitzl, M.S. , Chronic stress modulates the use of spatial and stimulus-response learning strategies in mice and man, Neurobiol Learn Mem, vol. 90, no. 3, pp. 495-503.

Topic, B., Oitzl, M.S., Meijer, O.C., Huston, J.P., Silva, M.A.D. , Differential Susceptibility to Extinction-Induced Despair and Age-Dependent Alterations in the Hypothalamic-Pituitary-Adrenal Axis and Neurochemical Parameters, Neuropsychobiology, vol. 58, no. 3-4, pp. 138-153.

Brinks, V., de Kloet, E.R., Oitzl, M.S. , Strain specific fear behaviour and glucocorticoid response to aversive events: modelling PTSD in mice, Prog Brain Res, vol. 167, pp. 257-261.

2007

Schmidt, M.V., Oitzl, M.S., Steenbergen, P.J., Lachize, S.B., Wurst, W., Muller, M.B., de Kloet, E.R., Meijer, O.C. , Ontogeny of steroid receptor coactivators in the hippocampus and their role in regulating postnatal HPA axis function, Brain Res, vol. 1174, pp. 1-6.

de Jong, I.E., Oitzl, M.S., de Kloet, E.R. , Adrenalectomy prevents behavioural sensitisation of mice to cocaine in a genotype-dependent manner, Behav Brain Res, vol. 177, no. 2, pp. 329-339.

Oitzl, M.S. , Avoidance, Encyclopedia of Stress, vol. 2nd, New York, Elsevier / Academic Press, pp. 297-301.

Brinks, V., van der Mark, M.H., de Kloet, E.R., Oitzl, M.S. , Differential MR/GR activation in mice results in emotional states beneficial or impairing for cognition, Neural Plast, vol. 2007, no. Articlr ID, pp. 1-11.

Brinks, V., van der Mark, M.H., De Kloet, E.R., Oitzl, M.S. , Emotion and cognition in high and low stress sensitive mouse strains: a combined neuroendocrine and behavioral study in BALB/c and C57BL/6J mice, Front Behav Neurosci, vol. 1, no. 8, pp. 1-12.

Revsin, Y., Oitzl, M.S., Saravia, F.E., De Nicola, A.E., De Kloet, E.R. , Neuroendocrine markers in streptozotocin (STZ)-induced type 1 diabetes, Diabetologia, vol. 50, pp. S282-S283, 0684.

De Kloet, E.R., Oitzl, M.S., Vermetten, E. , Stress hormones and post traumatic stress disorder basic studies and clinical perspectives, Prog Brain Res, vol. 167, no. xviii, 320, Amsterdam, Elsevier, pp. 1-320.

Brinks, V., de Kloet, E.R., Oitzl, M.S. , Strain specific fear behaviour and glucocorticoid response to aversive events: modelling PTSD in mice, Stress Hormones and Post Traumatic Stress Disorder: Basic Studies and Clinical Perspectives, vol. 167, Amsterdam, Elsevier Science Bv, pp. 257-261.

Schwabe, L., Oitzl, M.S., Philippsen, C., Richter, S., Bohringer, A., Wippich, W., Schachinger, H. , Stress modulates the use of spatial versus stimulus-response learning strategies in humans, Learn Mem, vol. 14, no. 1, pp. 109-116.

2006

Schmidt, M.V., Deussing, J.M., Oitzl, M.S., Ohl, F., Levine, S., Wurst, W., Holsboer, F., Muller, M.B., de Kloet, E.R. , Differential disinhibition of the neonatal hypothalamic- pituitary-adrenal axis in brain-specific CRH receptor 1-knockout mice, Eur J Neurosci, vol. 24, no. 8, pp. 2291-2298.

De Kloet, E.R., Oitzl, M.S. , Cortisol and PTSD: Animal Experiments and Clinical Perspectives, PTSD, brain mechanisms and clinical implications, no. Part 1, New York, Springer, pp. 13-27.

Revsin, Y., van Wijk, D., Saravia, F.E., De Nicola, A.F., Oitzl, M.S., De Kloet, E.R. , HPA axis regulation reaches a new setpoint in acute and chronic type 1 diabetes: implications for brain pathology, Diabetologia, vol. 49, pp. 329-330.

Joels, M., Pu, Z., Wiegert, O., Oitzl, M.S., Krugers, H.J. , Learning under stress: how does it work?, Trends Cogn Sci, vol. 10, no. 4, pp. 152-158.

Schmidt, M.V., Enthoven, L., van der Mark, M.H., Levine, S., De Kloet, E.R., Oitzl, M.S. , The postnatal development of the hypothalamic-pituitary-adrenal axis in the mouse (vol 23, pg 125, 2003), Int J Dev Neurosci, vol. 24, no. 4, pp. 293-293.

2005

Schmidt, M.V., Levine, S., Oitzl, M.S., van der Mark, M.H., Muller, M.B., Holsboer, F., de Kloet, E.R. , Glucocorticoid receptor blockade disinhibits pituitary-adrenal activity during the stress hyporesponsive period of the mouse, Endocrinology, vol. 146, no. 3, pp. 1458-1464.

Dalm, S., Enthoven, L., Meijer, O.C., van der Mark, M.H., Karssen, A.M., de Kloet, E.R., Oitzl, M.S. , Age-related changes in hypothalamic-pituitary-adrenal axis activity of male C57BL/6J mice, Neuroendocrinology, vol. 81, no. 6, pp. 372-380.

Meijer, O.C., Topic, B., Steenbergen, P.J., Jocham, G., Huston, J.P., Oitzl, M.S. , Correlations between hypothalamus-pituitary-adrenal axis parameters depend on age and learning capacity, Endocrinology, vol. 146, no. 3, pp. 1372-1381.

Revsin, Y., Dalm, S., Saravia, F.E., Oitzl, M.S., De Nicola, A.F., De Kloet, E.R. , HPA axis regulation in type 1 diabetes, Diabetologia, vol. 48, pp. A234-A234.

Schmidt, M.V., Oitzl, M.S., Muller, M.B., Ohl, F., Wurst, W., Holsboer, F., Levine, S., De Kloet, E.R. , Regulation of the developing hypothalamic-pituitary-adrenal axis in corticotropin releasing hormone receptor 1-deficient mice (vol 119, pg 589, 2003), Neuroscience, vol. 135, no. 4, pp. 1343-1343.

Oitzl, M.S., Enthoven, L., De Kloet, E.R. , Stress system regulation, glucocorticoid receptors and traumatic early life events, Eur Psychiatry, vol. 20, no. Suppl-1, pp. S102-S102.

Schmidt, M.V., Oitzl, M.S., Levine, S., De Kloet, E.R. , The HPA system during the postnatal development of CD1 mice and the effects of maternal deprivation (vol 139, pg 39, 2002), Developmental Brain Research, vol. 160, no. 2, pp. 287-287.

2004

Grootendorst, J., Enthoven, L., Dalm, S., de Kloet, E.R., Oitzl, M.S. , Increased corticosterone secretion and early-onset of cognitive decline in female apolipoprotein E-knockout mice, Behav Brain Res, vol. 148, no. 1-2, pp. 167-177.

Schmidt, M.V., Enthoven, L., van Woezik, J.H., Levine, S., de Kloet, E.R., Oitzl, M.S. , The dynamics of the hypothalamic-pituitary-adrenal axis during maternal deprivation, J Neuroendocrinol, vol. 16, no. 1, pp. 52-57.

Enthoven, L., Dalm, S., de Kloet, E.R., Oitzl, M.S. , Swim posture of mice does not affect performance in the water maze, Brain Res, vol. 1003, no. 1-2, pp. 36-41.

De Kloet, E.R., Karssen, A.M., Meijer, O.C., Oitzl, M.S. , Central effects of glucocorticoid antagonists: Preclinical studies, Biol Psychiatry, vol. 55, no. 8, Suppl-1, pp. 190S-191S.

de Jong, I.E.M., Oitzl, M.S., De Kloet, E.R. , Genetic background and glucocorticoid hormones contribute to individual differences in sensitivity of mice to cocaine, Behavioural Pharmacology, vol. 15, no. 5-6, pp. A13-A13.

2003

de Kloet, E.R., Oitzl, M.S. , Who cares for a stressed brain? The mother, the kid or both?, Neurobiol Aging, vol. 24 Suppl 1, pp. S61-5; discussion S67-8.

Schmidt, M.V., Enthoven, L., van der Mark, M.H., Levine, S., de Kloet, E.R., Oitzl, M.S. , The postnatal development of the hypothalamic-pituitary-adrenal axis in the mouse, Int J Dev Neurosci, vol. 21, no. 3, pp. 125-132.

Tolmacheva, E.A., Oitzl, M.S., Chepumov, S.A., van Luijtelaar, E.L.J.M. , Activity of the hypothalamus-pituitary-adrenal axis in female absence epileptic rats, Epilepsia, vol. 44, pp. 107-107.

Buitelaar, J.K., De Kloet, E.R., Oitzl, M.S. , Discussion to "Prenatal stress and cognitive development and temperament in infants" by Jan K. Buitelaar et al. and "Who cares for stress in the brain? The mother, the kid, or both" by E. Ronald de Kloet and Melly S. Oitzl, Neurobiol Aging, vol. 24, no. Supplement, pp. S67-S68.

de Jong, I.E.M., Oitzl, M.S., De Kloet, E.R. , Differential effects of glucocorticoids on the dopaminergic reward system in two genetically distinct mouse strains, Behavioural Pharmacology, vol. 14, no. Suppl-1, pp. S78-S78.

Schmidt, M.V., Oitzl, M.S., Muller, M.B., Ohl, F., Wurst, W., Holsboer, F., Levine, S., De Kloet, E.R. , Regulation of the developing hypothalamic-pituitary-adrenal axis in corticotropin releasing hormone receptor 1-deficient mice, Neuroscience, vol. 119, no. 2, pp. 589-595.

2002

Grootendorst, J., Kempes, M.M., Lucassen, P.J., Dalm, S., de Kloet, E.R., Oitzl, M.S. , Differential effect of corticosterone on spatial learning abilities in apolipoprotein E knockout and C57BL/6J mice, Brain Res, vol. 953, no. 1-2, pp. 281-285.

Schmidt, M.V., Oitzl, M.S., Levine, S., de Kloet, E.R. , The HPA system during the postnatal development of CD1 mice and the effects of maternal deprivation, Brain Res Dev Brain Res, vol. 139, no. 1, pp. 39-49.

de Kloet, E.R., Grootendorst, J., Karssen, A.M., Oitzl, M.S. , Gene x environment interaction and cognitive performance: animal studies on the role of corticosterone, Neurobiol Learn Mem, vol. 78, no. 3, pp. 570-7.

van Acker, S.A., Oitzl, M.S., Fluttert, M.F., de Kloet, E.R. , Centrally regulated blood pressure response to vasoactive peptides is modulated by corticosterone, J Neuroendocrinol, vol. 14, no. 1, pp. 56-63.

De Kloet, E.R., Oitzl, M.S., Vreugdenhil, E. , Brain corticosteroid receptors and responsive genes: Targets for therapy of stress-related disorders, Br J Pharmacol, vol. 135, pp. Suppl, 401P.

2001

Oitzl, M.S., Reichardt, H.M., Joels, M., de Kloet, E.R. , Point mutation in the mouse glucocorticoid receptor preventing DNA binding impairs spatial memory, PNAS, vol. 98, no. 22, pp. 12790-12795.

Schaaf, M.J., Workel, J.O., Lesscher, H.M., Vreugdenhil, E., Oitzl, M.S., de Kloet, E.R. , Correlation between hippocampal BDNF mRNA expression and memory performance in senescent rats, Brain Res, vol. 915, no. 2, pp. 227-33.

Grootendorst, J., de Kloet, E.R., Vossen, C., Dalm, S., Oitzl, M.S. , Repeated exposure to rats has persistent genotype-dependent effects on learning and locomotor activity of apolipoprotein E knockout and C57Bl/6 mice, Behav Brain Res, vol. 125, no. 1-2, pp. 249-59.

Grootendorst, J., Oitzl, M.S., Dalm, S., Enthoven, L., Schachner, M., de Kloet, E.R., Sandi, C. , Stress alleviates reduced expression of cell adhesion molecules (NCAM, L1), and deficits in learning and corticosterone regulation of apolipoprotein E knockout mice, Eur J Neurosci, vol. 14, no. 9, pp. 1505-1514.

Workel, J.O., Oitzl, M.S., Fluttert, M.F., Lesscher, H., Karssen, A.M., de Kloet, E.R. , Differential and age-dependent effects of maternal deprivation on the hypothalamic-pituitary-adrenal axis of brown norway rats from youth to senescence, J Neuroendocrinol, vol. 13, no. 7, pp. 569-80.

Sibug, R.M., Oitzl, M.S., Workel, J.O., de Kloet, E.R. , Maternal deprivation increases 5-HT(1A) receptor expression in the CA1 and CA3 areas of senescent Brown Norway rats, Brain Res, vol. 912, no. 1, pp. 95-8.

Oitzl, M.S. , Animal models of (traumatic) early life events: vulnerability to stress and cognition in later life, De neurobiologische en klinische aspecten van emotie en geheugen na psychotrauma, pp. 17-32.

Grootendorst, J., de Kloet, E.R., Dalm, S., Oitzl, M.S. , Reversal of cognitive deficit of apolipoprotein E knockout mice after repeated exposure to a common environmental experience, Neuroscience, vol. 108, no. 2, pp. 237-47.

2000

Oitzl, M.S., Workel, J.O., Fluttert, M.F., Frosch, F., De Kloet, E.R. , Maternal deprivation affects behaviour from youth to senescence: amplification of individual differences in spatial learning and memory in senescent Brown Norway rats, Eur J Neurosci, vol. 12, no. 10, pp. 3771-3780.

Dalm, S., Grootendorst, J., de Kloet, E.R., Oitzl, M.S. , Quantification of swim patterns in the Morris water maze, Behav Res Methods Instrum Comput, vol. 32, no. 1, pp. 134-139.

de Kloet, E.R., Van Acker, S.A., Sibug, R.M., Oitzl, M.S., Meijer, O.C., Rahmouni, K., de Jong, W. , Brain mineralocorticoid receptors and centrally regulated functions, Kidney Int, vol. 57, no. 4, pp. 1329-36.

Fluttert, M.F., Dalm, S., Oitzl, M.S. , A refined method for sequential blood sampling by tail incision in rats, Lab Anim, vol. 34, no. 4, pp. 372-378.

Oitzl, M.S., Grootendorst, J., Joels, M., Reichardt, H.M., Schutz, G., De Kloet, E.R. , Facilitation of spatial learning requires DNA-binding of the glucocorticoid receptor, Eur J Neurosci, vol. 12, pp. 170-170.

1999

de Kloet, E.R., Oitzl, M.S., Joels, M. , Stress and cognition: are corticosteroids good or bad guys?, Trends Neurosci, vol. 22, no. 10, pp. 422-6.

Schaaf, M.J., Sibug, R.M., Duurland, R., Fluttert, M.F., Oitzl, M.S., De Kloet, E.R., Vreugdenhil, E. , Corticosterone effects on BDNF mRNA expression in the rat hippocampus during morris water maze training, Stress, vol. 3, no. 2, pp. 173-183.

1998

Oitzl, M.S., Fluttert, M.F., de Kloet, E.R. , Acute blockade of hippocampal glucocorticoid receptors facilitates spatial learning in rats, Brain Res, vol. 797, no. 1, pp. 159-162.

Meijer, O.C., Kortekaas, R., Oitzl, M.S., de Kloet, E.R. , Acute rise in corticosterone facilitates 5-HT(1A) receptor-mediated behavioural responses, Eur J Pharmacol, vol. 351, no. 1, pp. 7-14.

De Kloet, E.R., Vreugdenhil, E., Oitzl, M.S., Joels, M. , Brain corticosteroid receptor balance in health and disease, Endocr Rev, vol. 19, no. 3, pp. 269-301.

Oitzl, M.S., Fluttert, M.F., Sutanto, W., de Kloet, E.R. , Continuous blockade of brain glucocorticoid receptors facilitates spatial learning and memory in rats, Eur J Neurosci, vol. 10, no. 12, pp. 3759-3766.

Ohl, F., Oitzl, M.S., Fuchs, E. , Assessing cognitive functions in tree shrews: visuo-spatial and spatial learning in the home cage, J Neurosci Methods, vol. 81, no. 1-2, pp. 35-40.

Grootendorst, J., Dalm, S., De Kloet, E.R., Oitzl, M.S. , Spatial learning of apolipoprotein E knockout mice in a water maze: Influence of repeated exposure to rats, Brain Res, vol. 809, no. 1, pp. A29-A29.

1997

Workel, J.O., Oitzl, M.S., Ledeboer, A., De Kloet, E.R. , The Brown Norway rat displays enhanced stress-induced ACTH reactivity at day 18 after 24-h maternal deprivation at day 3, Brain Res Dev Brain Res, vol. 103, no. 2, pp. 199-203.

van Haarst, A.D., Oitzl, M.S., de Kloet, E.R. , Facilitation of feedback inhibition through blockade of glucocorticoid receptors in the hippocampus, Neurochem Res, vol. 22, no. 11, pp. 1323-1328.

Oitzl, M.S., de Kloet, E.R., Joels, M., Schmid, W., Cole, T.J. , Spatial learning deficits in mice with a targeted glucocorticoid receptor gene disruption, Eur J Neurosci, vol. 9, no. 11, pp. 2284-2296.

Bhatnagar, M., Cintra, A., Chadi, G., Lindberg, J., Oitzl, M.S., De Kloet, E.R., Moller, A., Agnati, L.F., Fuxe, K. , Neurochemical changes in the hippocampus of the brown Norway rat during aging, Neurobiol Aging, vol. 18, no. 3, pp. 319-327.

Oitzl, M.S., Mulder, M., Lucassen, P.J., Havekes, L.M., Grootendorst, J., de Kloet, E.R. , Severe learning deficits in apolipoprotein E-knockout mice in a water maze task, Brain Res, vol. 752, no. 1-2, pp. 189-196.

De Kloet, E.R., Vreugdenhil, E., Oitzl, M.S., Joels, M. , Glucocorticoid feedback resistance, Trends Endocrinol Metab, vol. 8, no. 1, pp. 26-33.

Oitzl, M.S., van Haarst, A.D., de Kloet, E.R. , Behavioral and neuroendocrine responses controlled by the concerted action of central mineralocorticoid (MRS) and glucocorticoid receptors (GRS), Psychoneuroendocrinology, vol. 22, no. Suppl-1, pp. S87-S93.

De Kloet, E.R., Oitzl, M.S. , Special issue dedicated to Dr. Bruce S. McEwen - Preface, Neurochem Res, vol. 22, no. 11, pp. 1319-1320.

1996

van Haarst, A.D., Oitzl, M.S., Workel, J.O., de Kloet, E.R. , Chronic brain glucocorticoid receptor blockade enhances the rise in circadian and stress-induced pituitary-adrenal activity, Endocrinology, vol. 137, no. 11, pp. 4935-4943.

Rots, N.Y., Cools, A.R., Oitzl, M.S., de Jong, J., Sutanto, W., de Kloet, E.R. , Divergent prolactin and pituitary-adrenal activity in rats selectively bred for different dopamine responsiveness, Endocrinology, vol. 137, no. 5, pp. 1678-1686.

van Haarst, A.D., Welberg, L.A., Sutanto, W., Oitzl, M.S., de Kloet, E.R. , 11 beta-Hydroxysteroid dehydrogenase activity in the hippocampus: implications for in vivo corticosterone receptor binding and cell nuclear retention, J Neuroendocrinol, vol. 8, no. 8, pp. 595-600.

Rots, N.Y., Workel, J., Oitzl, M.S., Berod, A., Rostene, W., Cools, A.R., De Kloet, E.R. , Development of divergence in dopamine responsiveness in genetically selected rat lines is preceded by changes in pituitary-adrenal activity, Brain Res Dev Brain Res, vol. 92, no. 2, pp. 164-171.

1995

Van Eekelen, J.A., Oitzl, M.S., De Kloet, E.R. , Adrenocortical hyporesponsiveness and glucocorticoid feedback resistance in old male brown Norway rats, J Gerontol A Biol Sci Med Sci, vol. 50A, no. 2, pp. B83-B89.

Oitzl, M.S., van Haarst, A.D., Sutanto, W., de Kloet, E.R. , Corticosterone, brain mineralocorticoid receptors (MRs) and the activity of the hypothalamic-pituitary-adrenal (HPA) axis: the Lewis rat as an example of increased central MR capacity and a hyporesponsive HPA axis, Psychoneuroendocrinology, vol. 20, no. 6, pp. 655-675.

1994

Meijer, O.C., Oitzl, M.S., de Kloet, E.R. , Adrenalectomy leads to a different responsiveness to 8-OH-DPAT in a water-maze learning task, Ann N Y Acad Sci, vol. 746, pp. 408-10.

de Kloet, E.R., Rots, N.Y., van den Berg, D.T., Oitzl, M.S. , Brain mineralocorticoid receptor function, Ann N Y Acad Sci, vol. 746, pp. 8-20; discussion 20-1, 64-7.

Oitzl, M.S., Fluttert, M.F., de Kloet, E.R. , The effect of corticosterone on reactivity to spatial novelty is mediated by central mineralocorticosteroid receptors, Eur J Neurosci, vol. 6, no. 7, pp. 1072-1079.

Cintra, A., Lindberg, J., Chadi, G., Tinner, B., Moller, A., Gustafsson, J.A., De Kloet, E.R., Oitzl, M.S., Nishikawa, K., Agnati, L.F. , Basic fibroblast growth factor and steroid receptors in the aging hippocampus of the brown Norway rat: immunocytochemical analysis in combination with stereology, Neurochem Int, vol. 25, no. 1, pp. 39-45.

De Kloet, E.R., Oitzl, M.S., Schobitz, B. , Cytokines and the brain corticosteroid receptor balance: relevance to pathophysiology of neuroendocrine-immune communication, Psychoneuroendocrinology, vol. 19, no. 2, pp. 121-134.

1993

Oitzl, M.S., van Oers, H., Schobitz, B., de Kloet, E.R. , Interleukin-1 beta, but not interleukin-6, impairs spatial navigation learning, Brain Res, vol. 613, no. 1, pp. 160-163.

de Kloet, E.R., Sutanto, W., van den Berg, D.T., Carey, M.P., van Haarst, A.D., Hornsby, C.D., Meijer, O.C., Rots, N.Y., Oitzl, M.S. , Brain mineralocorticoid receptor diversity: functional implications, J Steroid Biochem Mol Biol, vol. 47, no. 1-6, pp. 183-190.

de Kloet, E.R., Oitzl, M.S., Joels, M. , Functional implications of brain corticosteroid receptor diversity, Cell Mol Neurobiol, vol. 13, no. 4, pp. 433-455.

Oitzl, M.S., Josephy, M., Spruijt, B.M. , An ACTH/MSH(4-9) analog counteracts the behavioral effects of a mineralocorticoid receptor antagonist, Pharmacol Biochem Behav, vol. 44, no. 2, pp. 447-450.

Oitzl, M.S., Sutanto, W., Houtzager, S., De Kloet, E.R. , Brain Corticosteroid Receptors and Stress Responsiveness in the Lewis Rat, Neuropsychopharmacology, vol. 9, no. 2, pp. S171-S172.

De Kloet, E.R., Oitzl, M.S., Joels, M. , Mineralo (Type-1) and Glucocorticoid (Type-2) Receptors in Brain - Behavioral Biochemical and Electrophysiological Studies, Neuropsychopharmacology, vol. 9, no. 2, pp. S4-S4.

van Haarst, A.D., Oitzl, M.S., De Kloet, E.R. , Nonacute Effects of Anti-Glucocorticoid Injection Into the Rat Cerebroventricular System, Neuropsychopharmacology, vol. 9, no. 2, pp. S139-S140.

1992

Oitzl, M.S., de Kloet, E.R. , Selective corticosteroid antagonists modulate specific aspects of spatial orientation learning, Behav Neurosci, vol. 106, no. 1, pp. 62-71.

De Kloet, E.R., Oitzl, M.S., Joels, M. , Corticosteroid receptor diversity in hippocampus: neuronal activity and spatial learning, Stress: Neuroendocrine and Molecular Approaches, vol. 1, New York, USA, Gordon and Breach Science Publishers SA, pp. 735-749.

Sutanto, W., Oitzl, M.S., Rots, N.Y., Schobitz, B., Van den Berg, D.T.W.M., van Dijken, H.H., Mos, J., Cools, A.R., Tilders, F.J., Koolhaas, J.M., De Kloet, E.R. , Corticosteroid receptor plasticity in the central nervous system of various rat models, Endocr Regul, vol. 26, no. 3, pp. 111-118.

1991

van Eekelen, J.A., Rots, N.Y., Sutanto, W., Oitzl, M.S., de Kloet, E.R. , Brain corticosteroid receptor gene expression and neuroendocrine dynamics during aging, J Steroid Biochem Mol Biol, vol. 40, no. 4-6, pp. 679-683.

de Kloet, E.R., Joels, M., Oitzl, M.S., Sutanto, W. , Implication of brain corticosteroid receptor diversity for the adaptation syndrome concept, Methods Achiev Exp Pathol, vol. 14, pp. 104-132.

De Kloet, E.R., Sutanto, W., Rots, N., van Haarst, A., van den Berg, D.T., Oitzl, M.S., van Eekelen, A., Voorhuis, D. , Plasticity and function of brain corticosteroid receptors during aging, Acta Endocrinologica, vol. 125, no. 6, Suppl 1, pp. 65-72.

1990

Oitzl, M.S., Hasenohrl, R.U., Huston, J.P. , Reinforcing effects of peripherally administered substance P and its C-terminal sequence pGlu6-SP6-11 in the rat, Psychopharmacology, vol. 100, no. 3, pp. 308-315.

1989

Hasenöhrl, R.U., Oitzl, M.S., Huston, J.P. , Conditioned place preference in the corral: a procedure for measuring reinforcing properties of drugs, J Neurosci Methods, vol. 30, no. 2, pp. 141-146.

Huston, J.P., Oitzl, M.S. , The relationship between reinforcement and memory: parallels in the rewarding and mnemonic effects of the neuropeptide substance P, Neurosci Biobehav Rev, vol. 13, no. 2-3, pp. 171-180.

1988

Oitzl, M.S., Hasenöhrl, R., Huston, J.P. , Reinforcing properties of substance P in the region of the nucleus basalis magnocellularis in rats, Neuropharmacology, vol. 27, no. 7, pp. 749-756.

1987

Oitzl, M.S., Boucke, K., Huston, J.P. , Reinforcing properties of substance P in the lateral hypothalamus revealed by conditioned place preference, Pharmacology Biochemistry and Behavior, vol. 28, no. 4, pp. 511-515.

1985

Oitzl, M.S., Koroleva, V. I, Bures, J. , D-ala2-Metenkephalinamide blocks the synaptically elicited cortical spreading depression in rats, Cellular and Mol Life Sci (Experientia), vol. 41, no. 5, pp. 625-627.

Buresova, O., Bures, J., Oitzl, M.S., Zahalka, A. , Radial maze in the water tank: an aversively motivated spatial working memory task, Physiol Behav, vol. 34, no. 6, pp. 1003-1005.

Koroleva, V. I, Oitzl, M.S., Bures, J. , Threshold of synaptically elicited cortical spreading depression: drug-induced changes in rats, Electroencephalogr Clin Neurophysiol, vol. 60, no. 1, pp. 55-64.

1984

Oitzl, M.S., Huston, J.P. , Electroencephalographic spreading depression and concomitant behavioral changes induced by intrahippocampal injections of ACTH1-24 and D-Ala2-Met-enkephalinamide in the rat, Brain Res, vol. 308, no. 1, pp. 33-42.

Buresova, O., Bures, J., Oitzl, M.S., Zahalka, A. , Radial Maze in A Water Tank - An Aversively Motivated Working Memory Task, Physiologia Bohemoslovaca, vol. 33, no. 6, pp. 522-523.

Koroleva, V. I, Oitzl, M.S., Bures, J. , Synaptically Elicited Spreading Depression - Drug-Induced Changes of Threshold, Physiologia Bohemoslovaca, vol. 33, no. 6, pp. 540-541.

1983

Oitzl, M.S., Huston, J.P. , Behavioral-Effects by Acth1-24 and D-Ala2-Metenkephalinamide - Physiological-Activity Or Concomitants of Spreading Depression, Behav Brain Res, vol. 8, no. 2, pp. 262-263.

1981

Sprick, U., Oitzl, M.S., Ornstein, K., Huston, J.P. , Spreading depression induced by microinjection of enkephalins into the hippocampus and neocortex, Brain Res, vol. 210, no. 1-2, pp. 243-252.

Melly currently supervises the following students:

03/05/2011

Medical Pharmacology